{"id":5330,"date":"2025-04-25T04:47:57","date_gmt":"2025-04-24T21:47:57","guid":{"rendered":"https:\/\/avidabioscience.com\/?p=5330"},"modified":"2025-04-25T04:47:57","modified_gmt":"2025-04-24T21:47:57","slug":"penyebab-penyakit-lupus","status":"publish","type":"post","link":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/","title":{"rendered":"Apa penyebab terjadinya penyakit lupus?"},"content":{"rendered":"
\"\"<\/div><\/div><\/div>
\"\"<\/div><\/div><\/div>
\"\"<\/div><\/div><\/div>
\"\"<\/div><\/div><\/div><\/div>
<\/i><\/div>
<\/i><\/div><\/div><\/div>

Lupus merupakan penyakit autoimun kronis yang menyebabkan peradangan di berbagai macam organ. Penyakit lupus hingga saat ini tidak memiliki etiologi (penyebab) yang definitif. Mekanisme etiologinya melibatkan interaksi multifaktorial antara kerentanan genetik, ketidakseimbangan hormonal, paparan lingkungan, serta etnis dan geografi (Rahman & Isenberg 2008; Tsokos 2011; James et al. 1997). Kombinasi faktor-faktor ini memicu hilangnya toleransi imun terhadap jaringan tubuh sendiri.<\/span><\/p>\n

1. <\/span>Faktor Genetik<\/b><\/h3>\n

Genetik berperan signifikan dalam kerentanan lupus. Studi pada kembar identik menunjukkan tingkat konkordansi 24\u201358% dibandingkan 3\u201310% pada kembar fraternal (Tsokos 2011). Riwayat lupus di dalam keluarga meningkatkan risiko munculnya penyakit lupus, terutama pada kerabat tingkat pertama (Rahman & Isenberg 2008).<\/span><\/p>\n

2. <\/span>Hormonal<\/b><\/h3>\n

Lupus lebih prevalen pada wanita usia reproduktif (9:1 rasio wanita:pria). Estrogen merangsang aktivasi sel B dan T, sementara defisiensi DHEA (hormon androgen) mengurangi imunosupresi alami (Costenbader et al. 2007). Pria dengan sindrom Klinefelter (XXY) juga berisiko tinggi. Hal ini memperkuat kaitan hormon seks dengan patogenesis lupus (Scofield et al. 2008).<\/span><\/p>\n

3. <\/span>Lingkungan<\/b><\/h3>\n

Paparan sinar UV merangsang keratinosit dan produksi autoantibodi (Lehmann et al. 1990). Paparan silika, rokok, dan pewarna rambut juga diidentifikasi sebagai pemicu potensial (Rahman & Isenberg 2008).<\/span><\/p>\n

4. <\/span>Etnis dan Geografi<\/b><\/h3>\n

Prevalensi lupus lebih tinggi pada kelompok etnis Afrika-Amerika, Hispanik, dan Asia dibandingkan dengan kelompok etnis Kaukasia (Helmick et al. 2008). Di AS, insiden lupus pada populasi Hispanik Nogales (100\/100.000) lebih tinggi daripada populasi Kaukasia di Minnesota (40\/100.000) (Uramoto et al. 1999; Balluz et al. 2001).<\/span><\/p>\n

Referensi<\/b><\/p>\n

    \n
  • Balluz, L., et al. (2001). <\/span>Am J Epidemiol<\/span><\/i>.<\/span><\/li>\n
  • Costenbader, K.H., et al. (2007). <\/span>Arthritis Rheum<\/span><\/i>.<\/span><\/li>\n
  • Helmick, C.G., et al. (2008). <\/span>Arthritis Rheum<\/span><\/i>.<\/span><\/li>\n
  • James, J.A., et al. (1997). <\/span>J Clin Invest<\/span><\/i>.<\/span><\/li>\n
  • Lehmann, P., et al. (1990). <\/span>J Am Acad Dermatol<\/span><\/i>.<\/span><\/li>\n
  • Rahman, A., & Isenberg, D. (2008). <\/span>N Engl J Med<\/span><\/i>.<\/span><\/li>\n
  • Scofield, R.H., et al. (2008). <\/span>Arthritis Rheum<\/span><\/i>.<\/span><\/li>\n
  • Tsokos, G. (2011). <\/span>N Engl J Med<\/span><\/i>.<\/span><\/li>\n
  • Uramoto, K.M., et al. (1999). <\/span>Arthritis Rheum<\/span><\/i>.<\/span><\/li>\n<\/ul>\n

    Untuk informasi lebih lanjut, hubungi tim kami di AVIDA Bioscience!<\/span><\/i><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":5331,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[60,46],"tags":[44,45],"class_list":["post-5330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-autoimunitas","category-learning-hub","tag-learning-hub","tag-proteomic"],"acf":[],"yoast_head":"\nApa penyebab terjadinya penyakit lupus? - AVIDA Bioscience<\/title>\n<meta name=\"description\" content=\"Lupus merupakan penyakit autoimun kronis yang menyebabkan peradangan di berbagai macam organ.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/\" \/>\n<meta property=\"og:locale\" content=\"id_ID\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Apa penyebab terjadinya penyakit lupus? - AVIDA Bioscience\" \/>\n<meta property=\"og:description\" content=\"Lupus merupakan penyakit autoimun kronis yang menyebabkan peradangan di berbagai macam organ.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/\" \/>\n<meta property=\"og:site_name\" content=\"AVIDA Bioscience\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-24T21:47:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"1350\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Ditulis oleh\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimasi waktu membaca\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 menit\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/avidabioscience.com\/id\/#\/schema\/person\/ee3a7a37bbad73d09a817d30e95ba7d2\"},\"headline\":\"Apa penyebab terjadinya penyakit lupus?\",\"datePublished\":\"2025-04-24T21:47:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/\"},\"wordCount\":849,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/#organization\"},\"image\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png\",\"keywords\":[\"Learning Hub\",\"Proteomic\"],\"articleSection\":[\"Autoimunitas\",\"Learning Hub\"],\"inLanguage\":\"id\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/\",\"url\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/\",\"name\":\"Apa penyebab terjadinya penyakit lupus? - AVIDA Bioscience\",\"isPartOf\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png\",\"datePublished\":\"2025-04-24T21:47:57+00:00\",\"description\":\"Lupus merupakan penyakit autoimun kronis yang menyebabkan peradangan di berbagai macam organ.\",\"breadcrumb\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#breadcrumb\"},\"inLanguage\":\"id\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"id\",\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#primaryimage\",\"url\":\"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png\",\"contentUrl\":\"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png\",\"width\":1080,\"height\":1350},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/avidabioscience.com\/id\/avida-bioscience\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Apa penyebab terjadinya penyakit lupus?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/avidabioscience.com\/id\/#website\",\"url\":\"https:\/\/avidabioscience.com\/id\/\",\"name\":\"AVIDA Bioscience\",\"description\":\"Pure Science, Reliable Solutions\",\"publisher\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/avidabioscience.com\/id\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"id\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/avidabioscience.com\/id\/#organization\",\"name\":\"AVIDA Bioscience\",\"url\":\"https:\/\/avidabioscience.com\/id\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"id\",\"@id\":\"https:\/\/avidabioscience.com\/id\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/avidabioscience.com\/wp-content\/uploads\/2023\/12\/Avida-Color-2Lines-cropped.png\",\"contentUrl\":\"https:\/\/avidabioscience.com\/wp-content\/uploads\/2023\/12\/Avida-Color-2Lines-cropped.png\",\"width\":1637,\"height\":411,\"caption\":\"AVIDA Bioscience\"},\"image\":{\"@id\":\"https:\/\/avidabioscience.com\/id\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.instagram.com\/avida_bioscience\/\",\"https:\/\/www.linkedin.com\/company\/avida-bioscience\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/avidabioscience.com\/id\/#\/schema\/person\/ee3a7a37bbad73d09a817d30e95ba7d2\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"id\",\"@id\":\"https:\/\/avidabioscience.com\/id\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/a421a2efefcab4483e60616df5cf6dc03aeb2c633f655d8d77504b6873396f90?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/a421a2efefcab4483e60616df5cf6dc03aeb2c633f655d8d77504b6873396f90?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/avidabioscience.com\"],\"url\":\"https:\/\/avidabioscience.com\/id\/author\/admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Apa penyebab terjadinya penyakit lupus? - AVIDA Bioscience","description":"Lupus merupakan penyakit autoimun kronis yang menyebabkan peradangan di berbagai macam organ.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/","og_locale":"id_ID","og_type":"article","og_title":"Apa penyebab terjadinya penyakit lupus? - AVIDA Bioscience","og_description":"Lupus merupakan penyakit autoimun kronis yang menyebabkan peradangan di berbagai macam organ.","og_url":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/","og_site_name":"AVIDA Bioscience","article_published_time":"2025-04-24T21:47:57+00:00","og_image":[{"width":1080,"height":1350,"url":"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png","type":"image\/png"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Ditulis oleh":"admin","Estimasi waktu membaca":"2 menit"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#article","isPartOf":{"@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/"},"author":{"name":"admin","@id":"https:\/\/avidabioscience.com\/id\/#\/schema\/person\/ee3a7a37bbad73d09a817d30e95ba7d2"},"headline":"Apa penyebab terjadinya penyakit lupus?","datePublished":"2025-04-24T21:47:57+00:00","mainEntityOfPage":{"@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/"},"wordCount":849,"commentCount":0,"publisher":{"@id":"https:\/\/avidabioscience.com\/id\/#organization"},"image":{"@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#primaryimage"},"thumbnailUrl":"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png","keywords":["Learning Hub","Proteomic"],"articleSection":["Autoimunitas","Learning Hub"],"inLanguage":"id","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/","url":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/","name":"Apa penyebab terjadinya penyakit lupus? - AVIDA Bioscience","isPartOf":{"@id":"https:\/\/avidabioscience.com\/id\/#website"},"primaryImageOfPage":{"@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#primaryimage"},"image":{"@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#primaryimage"},"thumbnailUrl":"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png","datePublished":"2025-04-24T21:47:57+00:00","description":"Lupus merupakan penyakit autoimun kronis yang menyebabkan peradangan di berbagai macam organ.","breadcrumb":{"@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#breadcrumb"},"inLanguage":"id","potentialAction":[{"@type":"ReadAction","target":["https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/"]}]},{"@type":"ImageObject","inLanguage":"id","@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#primaryimage","url":"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png","contentUrl":"https:\/\/avidabioscience.com\/wp-content\/uploads\/2025\/04\/penyebab-penyakit-lupus.png","width":1080,"height":1350},{"@type":"BreadcrumbList","@id":"https:\/\/avidabioscience.com\/id\/2025\/04\/25\/penyebab-penyakit-lupus\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/avidabioscience.com\/id\/avida-bioscience\/"},{"@type":"ListItem","position":2,"name":"Apa penyebab terjadinya penyakit lupus?"}]},{"@type":"WebSite","@id":"https:\/\/avidabioscience.com\/id\/#website","url":"https:\/\/avidabioscience.com\/id\/","name":"AVIDA Bioscience","description":"Pure Science, Reliable Solutions","publisher":{"@id":"https:\/\/avidabioscience.com\/id\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/avidabioscience.com\/id\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"id"},{"@type":"Organization","@id":"https:\/\/avidabioscience.com\/id\/#organization","name":"AVIDA Bioscience","url":"https:\/\/avidabioscience.com\/id\/","logo":{"@type":"ImageObject","inLanguage":"id","@id":"https:\/\/avidabioscience.com\/id\/#\/schema\/logo\/image\/","url":"https:\/\/avidabioscience.com\/wp-content\/uploads\/2023\/12\/Avida-Color-2Lines-cropped.png","contentUrl":"https:\/\/avidabioscience.com\/wp-content\/uploads\/2023\/12\/Avida-Color-2Lines-cropped.png","width":1637,"height":411,"caption":"AVIDA Bioscience"},"image":{"@id":"https:\/\/avidabioscience.com\/id\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.instagram.com\/avida_bioscience\/","https:\/\/www.linkedin.com\/company\/avida-bioscience\/"]},{"@type":"Person","@id":"https:\/\/avidabioscience.com\/id\/#\/schema\/person\/ee3a7a37bbad73d09a817d30e95ba7d2","name":"admin","image":{"@type":"ImageObject","inLanguage":"id","@id":"https:\/\/avidabioscience.com\/id\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a421a2efefcab4483e60616df5cf6dc03aeb2c633f655d8d77504b6873396f90?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a421a2efefcab4483e60616df5cf6dc03aeb2c633f655d8d77504b6873396f90?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/avidabioscience.com"],"url":"https:\/\/avidabioscience.com\/id\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/posts\/5330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/comments?post=5330"}],"version-history":[{"count":1,"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/posts\/5330\/revisions"}],"predecessor-version":[{"id":5339,"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/posts\/5330\/revisions\/5339"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/media\/5331"}],"wp:attachment":[{"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/media?parent=5330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/categories?post=5330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/avidabioscience.com\/id\/wp-json\/wp\/v2\/tags?post=5330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}