{"id":5045,"date":"2025-03-03T02:43:55","date_gmt":"2025-03-02T19:43:55","guid":{"rendered":"https:\/\/avidabioscience.com\/?p=5045"},"modified":"2025-03-03T02:43:55","modified_gmt":"2025-03-02T19:43:55","slug":"bagaimana-sel-puasa","status":"publish","type":"post","link":"https:\/\/avidabioscience.com\/id\/2025\/03\/03\/bagaimana-sel-puasa\/","title":{"rendered":"Bagaimana Sel-Sel Tubuh Kita Bertahan Tanpa Asupan Makanan?"},"content":{"rendered":"
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Metabolisme Saat Puasa<\/b><\/h3>\n

Saat puasa, tubuh beralih dari metabolisme glukosa ke biomolekul\/building blocks lainnya. Dalam 8\u201312 jam pertama, glikogen hati diurai menjadi glukosa melalui glikogenolisis (Berg et al., 2002). Setelah cadangan glikogen habis, glukoneogenesis (pembentukan glukosa baru dari asam amino dan gliserol) di hati menjadi sumber utama glukosa untuk otak (Owen et al., 1967). Namun, proses ini tidak efisien dalam jangka panjang. Tubuh mengaktifkan ketogenesis yang menghasilkan keton (\u03b2-hidroksibutirat dan asetoasetat) dari asam lemak di mitokondria hati (Cahill, 2006). Keton menjadi bahan bakar utama otak, jantung, dan otot, sehingga mengurangi ketergantungan pada glukosa.<\/span><\/p>\n

Adaptasi Hormonal: Insulin, Glukagon, dan Growth Hormone<\/b><\/h3>\n

Penurunan insulin dan peningkatan glukagon selama puasa mengaktifkan lipolisis (pemecahan trigliserida menjadi asam lemak) di jaringan adiposa (Boron & Boulpaep, 2017). Asam lemak kemudian dioksidasi di hati dan otot untuk menghasilkan ATP. Selain itu, peningkatan growth hormone (GH) membantu mempertahankan massa otot dengan merangsang sintesis protein dan mobilisasi lemak (Ho et al., 1988). Kombinasi respons hormonal ini memastikan ketersediaan energi tanpa menghabiskan protein struktural.<\/span><\/p>\n

Mitokondria: Optimasi Produksi ATP<\/b><\/h3>\n

Puasa meningkatkan efisiensi mitokondria melalui <\/span>mitochondrial biogenesis<\/span> (pembentukan mitokondria baru) yang dipicu oleh aktivasi <\/span>PGC-1\u03b1<\/span> (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) (L\u00f3pez-Lluch et al., 2006). Adaptasi ini meningkatkan kapasitas oksidatif sel dan mengurangi produksi <\/span>reactive oxygen species<\/span> (ROS), menekan stres oksidatif.<\/span><\/p>\n

Kesimpulan<\/b><\/h3>\n

Puasa memicu serangkaian adaptasi seluler yang kompleks: peralihan metabolik ke keton, aktivasi autofagi, regulasi hormonal, dan peningkatan fungsi mitokondria. Mekanisme ini tidak hanya mempertahankan homeostasis energi tetapi juga berpotensi meningkatkan ketahanan sel terhadap stres patologis. Namun, durasi dan frekuensi puasa perlu disesuaikan dengan kondisi individu untuk menghindari efek negatif.<\/span><\/p>\n

Referensi:<\/b><\/p>\n

    \n
  • Berg, J.M., et al. (2002). <\/span>Biochemistry<\/span><\/i>.<\/span><\/li>\n
  • Owen, O.E., et al. (1967). <\/span>J. Clin. Invest<\/span><\/i>.<\/span><\/li>\n
  • Cahill, G.F. (2006). <\/span>Annu. Rev. Nutr<\/span><\/i>.<\/span><\/li>\n
  • Mizushima, N., et al. (2008). <\/span>Nature<\/span><\/i>.<\/span><\/li>\n
  • Yang, Z., & Klionsky, D.J. (2010). <\/span>Nat. Cell Biol<\/span><\/i>.<\/span><\/li>\n
  • Boron, W.F., & Boulpaep, E.L. (2017). <\/span>Medical Physiology<\/span><\/i>.<\/span><\/li>\n
  • Ho, K.Y., et al. (1988). <\/span>N. Engl. J. Med<\/span><\/i>.<\/span><\/li>\n
  • L\u00f3pez-Lluch, G., et al. (2006). <\/span>Proc. Natl. Acad. Sci. USA<\/span><\/i>.<\/span><\/li>\n<\/ul>\n

    Untuk informasi lebih lanjut, hubungi tim kami di AVIDA Bioscience!<\/span><\/i><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":5046,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[46,58],"tags":[44,45],"class_list":["post-5045","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-learning-hub","category-ramadhan-1446-h","tag-learning-hub","tag-proteomic"],"acf":[],"yoast_head":"\nBagaimana Sel-Sel Tubuh Kita Bertahan Tanpa Asupan Makanan? - AVIDA Bioscience<\/title>\n<meta name=\"description\" content=\"Puasa memicu peralihan metabolik ke keton, aktivasi autofagi, regulasi hormonal, dan peningkatan fungsi mitokondria.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/avidabioscience.com\/id\/2025\/03\/03\/bagaimana-sel-puasa\/\" \/>\n<meta property=\"og:locale\" content=\"id_ID\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bagaimana Sel-Sel Tubuh Kita Bertahan Tanpa Asupan Makanan? 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